Lyrica medication interaction

Lyrica, or pregabalin, is an analgesic. Lyrica is useful in relieving neuropathic pain, when the patient is diabetic. Central neuropathic pain also can be managed with the use of Lyrica. Lyrica can interact with certain drugs. Around 483 drugs are known to have interaction with Lyrica when used in combination with it. The drugs that can interact with Lyrica can be disseminated up to 2974 brands and drugs of generic names. Out of these 483 drugs, 4 drugs come under major category, implying that they can have major interactions with Lyrica. However, most of the drugs listed under these 483 drugs have only moderate interactions. Such varieties of drugs interacting moderately with Lyrica come to a total of 477. There are also 2 drugs which have minor interaction with Lyrica.

The drugs that can have major interactions with Lyrica are acetaminophen, propoxyphene, aspirin/caffeine and sodium oxybate. The drugs that moderately interact with Lyrica include dexbrompheniramine/pseudoephedrine, diphenhydramine, hydrocodone, chlorpheniramine, aripiprazole, pentazocine and salicylamide, among others. The two drugs that interact mildly with Lyrica are bilberry and evening primerose. However, certain common medications such as amitriptyline, clonazepam, duloxetine, cyclobenzaprine, escitalopram, oxycodone, tramadol, trazodone and alprazolam are checked for interaction with Lyrica. Lyrica can have interactions with herbal products too. Therefore, if Lyrica is taken orally in combination with herbal products, it can cause side effects. Therefore, it is advisable to consult your physician or pharmacist before starting this combination.



You should also bring to the notice of your physician if you develop symptoms such as drowsiness, with the use of Lyrica. This can happen if you are already on certain anti-anxiety drugs, anti-seizure drugs, medicines for sleep, narcotic pain relievers, muscle relaxants, tranquilizers or psychiatric medicines. Conversely, before use of any medicine when you are already on Lyrica, you should check the label on the pack to know about the precautions you have take while using that medicine. For example, medicines for cough and cold can cause drowsiness. It is therefore necessary that you ensure safety while using other medicines. All the interactions of Lyrica with the above listed drugs are not containable in a brief documentation. Your physician or pharmacist knows them in specified terms. You should also have a list of medicines that you are using and show it to your doctor or pharmacist before starting Lyrica. This can help concluding on the medicines that you can use in combination with Lyrica and eliminate the avoidable ones.

It is important to known that alcohol and benzodiazepines can potentially interact with Lyrica. These drugs can boost the side effects including dizziness, drowsiness and confusion in the mind. The side effects may also vary from person to person. It is therefore essential for you to consult your physician to know about the side effects that are specifically applicable to you, when you use alcohol, sleep medications or benzodiazepines. Like alcohol, anesthetics and barbiturates such as amobarbital, butalbital, pentobarbital and secobarbital also interact potentially with Lyrica. Also, benzodiazepines including alprazolam, clorazepate, estazolam and triazolam interact potentially with Lyrica. Opiates or narcotics such as hydrocodone, morphine and oxycodone have potential interaction with Lyrica.

Conclusively, avoid consuming alcohol if you are already on Lyrica, to avoid side effects caused by the interaction of Lyrica with alcohol. If you combine an anesthetic with Lyrica, it can increase drowsiness, memory loss and confusion. At times it can cause breathing difficulties too. Therefore, if you have to undergo any surgery, do not forget to inform your physician in case you are on Lyrica. The effects caused by barbiturates, benzodiazepine, narcotics and sleep medicines due to their interaction with Lyrica are similar to those of anesthetics. Last but not the least, avoid over dosage of Lyrica, particularly when you are using other drugs that can interact with Lyrica.